Research Studies

Published research on HBOT for Alzheimer's Disease & Cognitive Decline

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These publications include different levels of evidence—not necessarily clinical trials. PubMed indexing is not proof of benefit or an endorsement. Summaries are based on available PubMed abstracts, not a formal full-text quality assessment. Read the limitations as well as the findings; some papers report no benefit or potential harms.
Comparative clinical study 2020

Hyperbaric oxygen ameliorates cognitive impairment in patients with Alzheimer's disease and amnestic mild cognitive impairment. (opens PubMed in a new tab)

Chen J; Zhang F; Zhao L; Cheng C; Zhong R; Dong C; Le W — Alzheimer's & dementia (New York, N. Y.)

Plain English Summary

Patients with Alzheimer's disease or amnestic mild cognitive impairment showed some short-term improvements in cognitive scores following HBOT.

Limitations & context: The abstract does not describe a blinded randomized design. Short-term score changes do not establish prevention, cure, or slowed disease progression.

View on PubMed · PMID 32548235
Animal study with exploratory human cohort 2021

Hyperbaric oxygen therapy alleviates vascular dysfunction and amyloid burden in an Alzheimer's disease mouse model and in elderly patients. (opens PubMed in a new tab)

Shapira R; Gdalyahu A; Gottfried I; Sasson E; Hadanny A; Efrati S; Blinder P; Ashery U — Aging

Plain English Summary

The investigators studied vascular and amyloid changes in an Alzheimer's mouse model and also reported brain blood-flow and cognitive changes in older people with memory loss.

Limitations & context: Animal findings must not be presented as demonstrated Alzheimer's treatment effects in humans. The human work was exploratory.

View on PubMed · PMID 34499614

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting HBOT or any treatment. Individual results may vary.