Research Studies

Published research on HBOT for Long COVID / Post-COVID Syndrome

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These publications include different levels of evidence—not necessarily clinical trials. PubMed indexing is not proof of benefit or an endorsement. Summaries are based on available PubMed abstracts, not a formal full-text quality assessment. Read the limitations as well as the findings; some papers report no benefit or potential harms.

Randomized sham-controlled trial 2022

Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial. (opens PubMed in a new tab)

Zilberman-Itskovich S; Catalogna M; Sasson E; Elman-Shina K; Hadanny A; Lang E; Finci S; Polak N; Fishlev G; Korin C; Shorer R; Parag Y; Sova M; Efrati S — Scientific reports

Plain English Summary

Patients with persistent post-COVID symptoms showed improvement in several cognitive and symptom measures after HBOT compared with sham.

Limitations & context: This was a relatively small trial with short follow-up after treatment. It does not establish a cure or effectiveness for all Long COVID presentations.

View on PubMed · PMID 35821512

Prospective registry study 2025

Hyperbaric oxygen therapy for long COVID: a prospective registry. (opens PubMed in a new tab)

van Berkel J; Lalieu RC; Joseph D; Hellemons M; Lansdorp CA — Scientific reports

Plain English Summary

Some Long COVID patients reported meaningful improvement after HBOT, while others reported meaningful deterioration.

Limitations & context: There was no randomized control group. Both improvement and worsening should be considered when interpreting the registry.

View on PubMed · PMID 40759992

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting HBOT or any treatment. Individual results may vary.