Research Studies

Published research on HBOT for Necrotizing Soft Tissue Infections

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These publications include different levels of evidence—not necessarily clinical trials. PubMed indexing is not proof of benefit or an endorsement. Summaries are based on available PubMed abstracts, not a formal full-text quality assessment. Read the limitations as well as the findings; some papers report no benefit or potential harms.

Systematic review / meta-analysis 2023

The effect of hyperbaric oxygen therapy on the clinical outcomes of necrotizing soft tissue infections: a systematic review and meta-analysis. (opens PubMed in a new tab)

Huang C; Zhong Y; Yue C; He B; Li Y; Li J — World journal of emergency surgery : WJES

Plain English Summary

Observational studies associated HBOT with lower mortality in necrotizing soft-tissue infections, but did not show a significant reduction in amputations overall.

Limitations & context: The review explicitly describes the evidence as weak because the studies were retrospective. HBOT must not delay surgery.

View on PubMed · PMID 36966323

Retrospective national cohort 2024

Contemporary national outcomes of hyperbaric oxygen therapy in necrotizing soft tissue infections. (opens PubMed in a new tab)

Toppen W; Cho NY; Sareh S; Kjellberg A; Medak A; Benharash P; Lindholm P — PloS one

Plain English Summary

A national hospital database analysis associated HBOT with lower mortality and amputation risk, but longer admissions and greater costs.

Limitations & context: Even adjusted observational analyses cannot exclude selection bias or establish causation. Patients also received surgery.

View on PubMed · PMID 38512943

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting HBOT or any treatment. Individual results may vary.