Research Studies

Published research on HBOT for Parkinson's Disease

← Browse all conditions in the PubMed Research Library

These publications include different levels of evidence—not necessarily clinical trials. PubMed indexing is not proof of benefit or an endorsement. Summaries are based on available PubMed abstracts, not a formal full-text quality assessment. Read the limitations as well as the findings; some papers report no benefit or potential harms.

Systematic review / meta-analysis 2025

Hyperbaric Oxygen Therapy Improves Motor Symptoms, Sleep, and Cognitive Dysfunctions in Parkinson's Disease. (opens PubMed in a new tab)

Bu S; Liu W; Sheng X; Jin L; Zhao Q — Dementia and geriatric cognitive disorders

Plain English Summary

The review reported improvements in some motor, sleep, and cognitive measures when HBOT was compared with conventional drug treatment for Parkinson's disease.

Limitations & context: Pooled results depend on the quality and design of the included studies. This does not demonstrate a cure or disease-modifying effect.

View on PubMed · PMID 39571556

Preclinical animal and cell study 2022

Hyperbaric Oxygen Therapy Improves Parkinson's Disease by Promoting Mitochondrial Biogenesis via the SIRT-1/PGC-1α Pathway. (opens PubMed in a new tab)

Hsu HT; Yang YL; Chang WH; Fang WY; Huang SH; Chou SH; Lo YC — Biomolecules

Plain English Summary

Experiments in a toxin-induced mouse model and cultured cells examined whether HBOT could protect dopamine-related neurons and mitochondrial function.

Limitations & context: This is not a human treatment trial. Laboratory effects cannot establish effectiveness or safe protocols for people with Parkinson's disease.

View on PubMed · PMID 35625589

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting HBOT or any treatment. Individual results may vary.