Research Studies

Published research on HBOT for Radiation Cystitis & Proctitis

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These publications include different levels of evidence—not necessarily clinical trials. PubMed indexing is not proof of benefit or an endorsement. Summaries are based on available PubMed abstracts, not a formal full-text quality assessment. Read the limitations as well as the findings; some papers report no benefit or potential harms.
Randomized controlled trial — radiation cystitis 2019

Radiation-induced cystitis treated with hyperbaric oxygen therapy (RICH-ART): a randomised, controlled, phase 2-3 trial. (opens PubMed in a new tab)

Oscarsson N; Müller B; Rosén A; Lodding P; Mölne J; Giglio D; Hjelle KM; Vaagbø G; Hyldegaard O; Vangedal M; Salling L; Kjellberg A; Lind F; Ettala O; Arola O; Seeman-Lodding H — The Lancet. Oncology

Plain English Summary

The RICH-ART trial found greater improvement in patient-reported urinary symptoms with HBOT than with standard care for late radiation cystitis.

Limitations & context: The trial was not blinded. Transient sight- and hearing-related adverse events were reported, and eligibility criteria limit generalization.

View on PubMed · PMID 31537473
Randomized sham-controlled trial — radiation proctitis 2008

Hyperbaric oxygen treatment of chronic refractory radiation proctitis: a randomized and controlled double-blind crossover trial with long-term follow-up. (opens PubMed in a new tab)

Clarke RE; Tenorio LM; Hussey JR; Toklu AS; Cone DL; Hinojosa JG; Desai SP; Dominguez Parra L; Rodrigues SD; Long RJ; Walker MB — International journal of radiation oncology, biology, physics

Plain English Summary

Patients with chronic refractory radiation proctitis showed improved healing and bowel-related quality of life after HBOT compared with initial sham treatment.

Limitations & context: This applies to selected refractory proctitis patients. The crossover design and incomplete evaluable follow-up should be considered.

View on PubMed · PMID 18342453

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting HBOT or any treatment. Individual results may vary.